Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation. They are seeking a Preclinical Modeling and Simulation Intern to work with the DMPK department, focusing on developing and implementing quantitative models for drug candidates.
Responsibilities
- Develop and implement quantitative systems pharmacology (QSP) models of relevant diseases in collaboration with the pM&S team
- Source modeling techniques and approaches from literature sources or design novel models as necessary to address questions and inform decision making across programs
- Collect relevant data from published sources as necessary for model calibration
- Present and discuss research progress with the pM&S team, DMPK, and other stakeholders as appropriate
Skills
- Enrolled in a graduate program, majoring in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study
- Significant experience (2-4 years minimum) using a programming language such as Matlab, Python, R, or Julia to numerically solve systems of ordinary differential equations is required for this position
- Experience designing and implementing ordinary differential equation-based models of biological systems, including parameter optimization using time-series data
- Experience importing, processing, and visualizing data using one of the programming languages listed above
- History of publication and/or conference presentations in mathematical biology, quantitative pharmacology, or QSP
- Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization
- You must be enrolled in an advanced degree program if graduating before August 2026
- You must be available to work full-time, 40 hours per week from May – August 2026
- Knowledge of pharmacokinetics (PK), pharmacokinetic-pharmacynamic (PKPD) modeling, QSP, population pharmacokinetics (popPK), or graduate coursework in applied mathematics is desirable but not required
- Knowledge of modeling softwares commonly used in the pharmaceutical industry such as Phoenix WinNonlin, SimBiology, SimCyp, or MonolixSuite is desirable but not required
- Expertise in at least one specific disease area is desirable but not required
Benefits
- Free 24/7 onsite gym access and free access to group exercise classes
- Subsidized commuter benefits- transit and parking
- Provided meals—free breakfast daily!
- Career development opportunities and events, including C Suite engagement
- Social events—both intern-only and company-wide
- Location-specific perks and extras!
- Recognition of National Intern Day
Company Overview
Vertex Pharmaceuticals is focused on the discovery and development of small molecule drugs for the treatment of serious diseases. It was founded in 1989, and is headquartered in Boston, Massachusetts, USA, with a workforce of 5001-10000 employees. Its website is http://www.vrtx.com.
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