Drug Discovery Scientist (Medicinal Chemistry / Pharmacology)

Position: Drug hunters (chemists) or toxicologists Type: Hourly contract Compensation: $70-$100 per hour Location: Remote Commitment: 10–40 hours/week Role Responsibilities • Review and annotate datasets related to drug discovery, pharmacology, and safety biology • Interpret experimental outputs from target biology studies, biochemical assays, cellular models, and safety screens • Analyze relationships between compound structure, potency, selectivity, exposure, and toxicity signals • Identify mechanistic explanations behind efficacy or toxicity findings across discovery experiments • Distinguish meaningful biological signal from experimental artifacts, assay interference, or model limitations • Audit annotated datasets for biological, pharmacological, and safety accuracy • Validate structure–activity relationships, target engagement logic, and pharmacokinetic interpretations • Evaluate AI-generated reasoning on drug mechanism, toxicity risk, and safety margins • Ensure correct interpretation of dose-response relationships, exposure margins, and translational relevance • Contribute to annotation guidelines for drug discovery workflows, SAR, pharmacokinetics, toxicity mechanisms, and translational biology • Provide expertise on balancing potency, selectivity, safety, and developability • Advise on classification of toxicity findings, safety signals, and risk assessment frameworks • Review AI-generated reasoning on drug mechanism, target biology, toxicity, and pharmacokinetics • Assess whether conclusions logically follow from experimental evidence and biological context • Provide structured feedback to improve scientific rigor and reasoning in model outputs • Contribute to scientific standards documentation and training materials • Help define gold‑standard examples of drug discovery reasoning and toxicity interpretation • Support calibration workflows across pharmacology, toxicology, and translational biology Requirements • Advanced degree such as PhD, PharmD, DVM, MD, or MS with significant industry experience in medicinal chemistry, pharmacology, toxicology, chemical biology, molecular biology, pharmaceutical sciences, or biochemistry • Hands‑on experience in drug discovery or safety assessment including target validation through lead optimization • Experience in structure–activity relationship analysis • Experience in pharmacokinetics and ADME interpretation • Experience in toxicology and safety pharmacology studies • Experience interpreting in vitro and in vivo experimental data • Strong expertise in target biology and mechanism‑of‑action reasoning • Understanding of dose‑response relationships and exposure margins • Ability to interpret translational relevance between preclinical and clinical findings • Knowledge of toxicity mechanisms such as liver toxicity, cardiovascular liabilities, genotoxicity, or reproductive toxicity • Ability to evaluate safety findings for risk and program impact • Experience reviewing primary experimental data and study reports • Exceptional attention to scientific accuracy and mechanistic reasoning • Experience in pharmaceutical or biotechnology drug discovery teams • Background in lead optimization, translational biology, or nonclinical safety • Familiarity with DMPK workflows, safety biomarkers, and regulatory toxicology considerations • Experience contributing to cross‑functional discovery teams • Exposure to AI or ML tools applied to biomedical research